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Peer review Peer review information Nature Communications thanks Rudolf Oehler, Robert Hoffman and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

J Toxicol Environ Health B Crit Rev

This is generally mild and self-limiting, but if headaches persist beyond the first week or are significant, stopping use and consulting a doctor is the sensible approach rather than continuing through discomfort

Subcutaneous administration near the injury site provides both high local concentration and some systemic distribution as the peptide migrates to areas of damage throughout the body