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Originally proposed in HA-based micellar systems for tumor-targeted delivery, this mechanismspatial CD44-mediated localization of HA and ROS-triggered temporal GSH releaseis directly applicable to wound healing

2 Mechanisms of redox regulation in the CNS 2.1 GSH as an antioxidant in the brain The brain, being one of the most metabolically active organs in the body, requires a large share of oxygen relative to its mass

Benefits: Always using fresh peptides No worry about degradation Can adjust doses without wasting partially-used vials Trade-off: Slightly more frequent mixing (minor inconvenience for better quality)