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Constipation on Tirzepatide or Semaglutide (GLP-1): A Step-by-Step MD Fix Joshua Silva, MD Jan 31 5 min read Updated: Feb 2 Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD Definition Constipation on GLP-1 medications refers to infrequent, hard, or difficult-to-pass stools caused by medication-related slowing of gastrointestinal motility . The Quick Fix: How do I relieve constipation on GLP-1 medications