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The compound appears well-tolerated in animals at doses well above those producing metabolic effects
About the Compound AOD-9604 is a synthetic 16-amino-acid peptide with the sequence Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (YLRIVQCRSVEGSCGF) stabilized by a disulfide bond between the two cysteine residues
Similarly, although hepatic dysfunction can occur with large niacin doses (1-3 grams daily over months) causing elevated liver enzymes or jaundice, niacinamide at 100 mg is very unlikely to have any adverse effect on the liver
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