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Expert Rev Neurotherapeutics 15(7):719721
While oral vitamin B12 supplements must go through your digestive system before entering the bloodstream, vitamin B12 injections are delivered right to the bloodstream so you get the full benefits of the dosage
Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans
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