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One potential mechanism is thought to involve activation of the central nervous system, with the area postrema (AP) and nucleus of the solitary tract (NTS) and the intermediolateral nucleus (IML) of the spinal cord similarly activated by administration of GLP-1RA 29,30
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[57] Furthermore, semaglutide actively inhibits pro-inflammatory transcription factors such as NF-B and JNK
Start: 100 mcg daily
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