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Realistic 2026 Results: What the Data Shows Metric Typical IF Outcome (1012 Weeks) Weight Loss 711 pounds (roughly 35% of body weight) Fat Loss Primarily visceral (belly) fat Blood Pressure Significant reductions in those with high baseline levels Muscle Retention High (if paired with resistance training) Reduced calorie intake due to fewer meals Improved insulin sensitivity Increased fat burning during fasting periods However, IF does not directly suppress appetite, which is why many people struggle with hunger during fasting hours

LombardoFFiduciaMLunghiRMarchettiLPalumboARizzoFet al

Future prospective studies should adopt a more comprehensive methodological approach, including measures of insulin resistance (eg, HOMA-IR), hypoglycemia monitoring, and validated quality-of-life questionnaires, to better reflect the full impact of GLP-1 analogue therapy on patient outcomes

Can Ozempic be used in combination with other weight loss medications