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Braniste V, Al-Asmakh M, Kowal C, et al
This localized delivery and high gastric concentration may exert direct, proximity-dependent effects on the upper gastrointestinal microbiota and local epithelial barrier integrity before systemic absorption, a feature completely absent in injectable regimens
[26] showed that liraglutide-dependent weight loss relies on its binding to GLP-1Rs located mainly in POMC/CART (cocaine- and amphetamine-regulated transcript) anorexigenic neurons in the ARC, but an indirect inhibitory effect of agouti-related peptide (AgRP) orexigenic neurons via -aminobutyric acid (GABA)-ergic signaling was also observed
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