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GIPR agonism supports glucose-dependent insulin release and lipid metabolism, while GCGR activation is linked to increased energy expenditure, hepatic lipolysis, and thermogenesis processes that together distinguish it from earlier incretin-based research compounds such as semaglutide and tirzepatide

John Cawley, a professor of economics and public policy at Cornell University who has studied the economic impacts of obesity, has found that obesity essentially doubles a persons annual health care costs due to comorbidities such as heart disease, fatty liver disease and kidney disease

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