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As the kidneys receive ~ 25% of the cardiac output, a condition known as cardiorenal syndrome (CRS) can manifest when either the heart or the kidneys fail (Ronco et al
Neither has been tested in humans, and both operate through mechanisms fundamentally different from established nootropic peptides like Semax and Selank
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Compared to placebo, canagliflozin was associated with an increased risk of lower limb amputations (6.3 versus 3.4 participants with amputations per 1,000 person-years
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