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The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months
That means weekly shots are often needed in the beginning to keep energy and mood consistently up
Clinical observations in elderly populations show Epithalon treatment improves overall immune system parameters
Acknowledgements Not applicable Funding This research was supported by the Ministry of Science, Education and Sports, Republic of Croatia (grant number 108-1083570-3635)
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