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Patients with PCOS often experience insulin resistance, weight gain, and metabolic complicationsconditions for which GLP-1 medications are commonly prescribed
Which means in 2011, it expired
NNMT inhibition doesn't directly affect gut motility, so prolonged GI symptoms suggest an individual sensitivity rather than a universal mechanism
Moreover, GLP-1 RAs slow gastric emptying, thereby blunting postprandial glucose and lipid excursions, though diminished tolerance to this effect may develop during prolonged administration of extended-release preparations
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