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Metabolites, especially SCFAs, such as acetate, butyrate, propionate, and lactate, produced by the fermentation of carbohydrates, reach the systemic circulation and regulate various biological processes, including epigenetics, gene expression, and immune response [107]

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The genetic interactions between CYS4 and YAK1 , and between CYS4 and MCK1 , are conserved in mammalian cells Then, to check whether the regulation of Cys4p by Yak1p is conserved in mammalian cells, we tested the effect of the expression of DYRK1A in the human hepatoma HepG2 cell line