For individuals requiring supplementation due to confirmed deficiency or malabsorption, therapeutic doses vary considerably depending on the underlying cause: Dietary deficiency : 50150 micrograms daily orally, or cyanocobalamin tablets as prescribed Pernicious anaemia : Initially hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks, then maintenance injections every two to three months [3] Neurological involvement : More intensive regimens may be required, with hydroxocobalamin injections on alternate days until symptom improvement [3] NICE guidance emphasises that supplementation should be evidence-based rather than speculative
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HC Federica Montseny: Sonsoles Muoz Moreno, Ana Mara Ribao Verdugo, Mara Jess Fidalgo Baz, Isabel Vaquero Turio, Ana Mara Je Fidalgo Baz, Clementa Sanz Sanchez, Ana Mara Snchez Sempere, Javier Martnez Sanz, Mara Isabel Arratibel Elizondo
Emerging bioelectronics for brain organoid electrophysiology