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Allergy to GLP-1 or GIP Medications Those who have experienced allergic reactions to Semaglutide, Tirzepatide, or any GLP-1/GIP receptor agonist medications should avoid these treatments
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The concurrent GLP-1 and GIP arms drive glucose-dependent insulin secretion that offsets glucagon-induced gluconeogenesis, producing net euglycaemia alongside elevated lipolysis (Jastreboff et al., NEJM, 2023) [1]
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