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The Intracellular ferrous iron can be oxidized and exported by the membrane protein ferroportin (FPN), which currently is the unique iron efflux pump discovered that can release iron from cells (Ganz, 2005)
These findings suggest that vitamin D may contribute to venous protection by enhancing NO bioavailability through eNOS upregulation while simultaneously reducing the inflammation-associated NO production via iNOS suppression
Gonnella F, Konstantinidou F, Donato M, Gatta DMP, Peserico A, Barboni B, et al
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