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IL-4 secreted by activated T cells has anti-angiogenic effects by inhibiting VEGF production in RA FLS, which helps relieve RA ( + T cells population ( via activation of protein kinase C (PKC) / II and ERK-1/2, with concomitant down-regulation of the NF-B/p65 pathway ( via activating Smad-2/3 in RA ( ( Figure 1 )
The logic behind combining Cagrilintide with a GLP-1 agonist is straightforward
So for people that suffer from IBS, irritable bowel syndrome, or from colitis, or from other gut issues, There is a potential use for therapeutic peptides
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