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Herein, this study aims to develop an inhibitor to reduce dTTP and dCTP pools without general toxicity as an option for CML treatment
By attenuating NNMT activity, 5Amino1MQ has been observed in preclinical settings to elevate NAD+ availability, enhance metabolic flux, and upregulate downstream signaling programs associated with cellular stress responses and energy expenditure (e.g., SIRT1)
The most promising 5-Amino-1MQ benefits come from mouse studies
Blood for this study was collected during days 9.12.2019, 27.01.2020, 4.02.2020, 5.02.2020, 10.02-11.02.2021
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