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For people who are not at high risk of getting diabetes and have their blood pressure under control, it may be wise to wait

However, one study found that drug exposure was not clinically significant, and no dosing adjustments were necessary for most oral medications

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Clinical trials demonstrate that semaglutide can produce approximately 15% body weight reduction over 68 weeks, while tirzepatide can achieve about 21% reduction over 72 weeks when combined with lifestyle modifications in people without diabetes