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Phentermine is contraindicated in patients with cardiovascular disease, hyperthyroidism, glaucoma, and a history of drug abuse
Flavonoids, specifically naringenin and hesperidin, are able to inhibit the TGF- pathway, which is known to be a key regulator of fibroblast activation and collagen production
A separate check in the NIHs All of Us program found the main efficacy signal again, which strengthened confidence in the result
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