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I first stumbled upon tl;dr by a recommendation from my classmate when I was struggling to understand chemo-induced nausea and vomiting (CINV)
Rimm EB, Willett WC, Hu FB, Sampson L, Colditz GA, Manson JE, Hennekens C, and Stampfer MJ (1998)
While the nephroprotective effects of SGLT2i were initially derived from secondary endpoints of CV outcome trials (CVOTs), direct confirmation came from dedicated kidney focused trials: CREDENCE (Perkovic et al NEJM 2019| NephJC Summary), DAPA-CKD (Heerspink et al NEJM 2020| NephJC Summary) and finally EMPAKIDNEY (Herrington et al NEJM 2023| NephJC Summary)
However, there was moderate-quality evidence that probiotics improve recovery and may lead to improvements in overt HE, quality of life, and plasma ammonia concentrations
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