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To date, four primary types of PANoptosomes have been identified: the ZBP1-PANoptosome (comprising ZBP1, NLRP3, ASC, caspase-1, caspase-6, caspase-8, RIPK1 and RIPK3) [39], AIM2-PANoptosome (comprising AIM2, Pyrin, ZBP1, ASC, caspase-1, caspase-8, FADD, RIPK1 and RIPK3) [40], RIPK1-PANoptosome (comprising RIPK1, RIPK3, NLRP3, ASC, caspase-1 and caspase-8) [41] and NLRP12-PANoptosome (comprising NLRP12, ASC, caspase-8 and RIPK3) [42]
The stratum corneum showed a 2-hour lag, while the full epidermis required up to 7 hours for significant penetration
(2018), and Rossi et al
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