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Omzo's brand materials describe tirzepatide as offering "dual-hormone support that targets appetite, blood sugar, and metabolism for deeper, sustained progress." Clinical trials of tirzepatide (the active ingredient in Zepbound and Mounjaro) have shown substantial weight loss outcomes in studied populations, and some trials have shown greater average weight reduction with tirzepatide compared to semaglutide in head-to-head comparisons - though individual responses vary and neither medication is appropriate for all patients
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The expression of intestinal endocrine Lcells is regulated by several key receptors activated by short chain fatty acids (SCFAs), specific endogenous cannabinoids and bile acids, and the activation of these receptors increases the secretion of key intestinal peptides, such as GLP-1, GLP-2 and polypeptide YY (PYY) (de Vos et al., 2022)
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