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Some diseases that make you at higher risk of having a deficiency include gastritis, digestive diseases such as celiac disease or Crohns disease, HIV, or an alcohol abuse disorder
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NNMT consumes S-adenosylmethionine (SAM) as a methyl donor, so inhibiting NNMT could theoretically increase SAM availability for other methylation reactions
Possible side effects include injection-site reactions, temporary skin irritation from topical use, and in rare cases, the "copper uglies" phenomenon
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