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Freezing damages it

Ozempic Headache: Side Effect and Tips for Relief Key Takeaways Headaches can happen when starting Ozempic or other semaglutide medications, but they are often linked to dehydration, electrolyte imbalance, or low blood sugar rather than the drug itself

One reason is that semaglutide is processed in the body in a way that may involve the liver, even if it is not mainly broken down by the liver like some other drugs