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Intracellular activation of nitrofurantoin yields a radical anion that subsequently initiates Nrf2-dependent induction of glutamate-cysteine ligase and consequently a rise in glutathione

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The letter gives the recipient a chance to correct the issues and requires a response, usually within 15 days

Sequence:Gly-His-Lys (complexed with Cu) Origin: Naturally occurring human copper-binding tripeptide, synthesised as a Cu-chelated complex for laboratory research