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Conversely, FXR agonists reduce these lipid parameters in db/db mice, yet show no efficacy in FXR deficient mice (Yang et al., 2010)
The sustained GH elevation from DAC can increase side effects including water retention and insulin resistance
However, when the glucose load exceeds the renal glucose threshold, as is the case in people with uncontrolled hyperglycemia, glucose begins to appear in the urine a clinical finding termed glucosuria
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