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Recently, several retrospective studies of patients with T2D and CKD found that although use of GLP1-RA was associated with improved overall survival compared to use of DPP4i, there was no significant difference in cardiovascular outcomes 42,43
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Excess PyroGlu in a septic patient without enzymatic deficiency in the gamma-glutamyl cycle could be associated with the depletion of GSH, and therefore excessive oxidative stress and its negative consequences
1 If approved, an effective once-daily oral GLP-1 could significantly expand access by lowering delivery barriers, improving adherence for injection-averse patients, and alleviating distribution constraints often associated with injectable formulations
