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In the stage I trial, Bioglutid reduced fasting blood glucose by 1.8 mmol/L and glycosylated hemoglobin (HbA1c) by 0.9% in patients with type 2 diabetes, which was better than the single target GLP-1 analog
eWAT explants (500 mg) were digested in 1 mL DMEM supplemented with 2% fatty acidfree BSA (Sigma-Aldrich, 126575), HEPES (10 mM), Liberase TM (thermolysin medium) (25 g/mL) (Roche, 05401119001), and DNAse (250 g/mL) (Roche, 10104159001) for 1 hour at 37C
10.1038/s41574-023-00821-8 3 BeccutiG.BiolettoF.Parasiliti-CaprinoM.BensoA.GhigoE.CicolinA.et al (2024)
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