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The results presented by Novo Nordisk demonstrated reductions of up to 10% in biomarkers linked to neuroinflammation and Alzheimers disease a statistically significant change, but not large enough to have a clinical impact
In the penumbra and reperfused peri-infarct region, however, MSC-derived paracrine and vasoactive signals may improve microvascular oxygen delivery and reduce hypoxia-driven glycolysis [10, 14]
It should not be used during pregnancy, and safety in breastfeeding has not been established
Markku Lhteenvuo, a research director from the University of Eastern Finland, said: "It is possible that, in addition to factors such as reduced alcohol consumption, weight loss-related improvements in body image, or relief associated with better glycaemic control in diabetes, there may also be direct neurobiological mechanisms involved for example, through changes in the functioning of the brain's reward system." The researchers said these could include reducing some of the more damaging reward symptoms that affect people with depression such as the impulse to self-harm.
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