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Potential evening downsides The biggest risk with evening dosing is forgetting
The samples were incubated at 20 C for 12 h, then gradually warmed to 4 C over a 4-h period
Upon DNA-dependent transactivation (TA), GR dimers bind to GC-responsive elements, followed by transcriptional activation of genes associated with an increased risk of adverse effects including diabetes mellitus, peptic ulcer, Cushings syndrome, osteoporosis, hyperglycemia, skin and muscle atrophy, and many other complications [12]
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