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The widespread interest in GLP-1 receptor agonists for weight loss, particularly amid drug shortages, has renewed clinical and regulatory attention to their safety profile, yet the clinical profile of acute exposures remains poorly understood, wrote first author Jordan Miller, a researcher with The University of Texas at San Antonio, and colleagues

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207-OR: Myostatin inhibition synergizes with GLP-1R agonism to accelerate weight loss in male, obese nonhuman primates

The defining distinction is receptor coverage: The addition of glucagon receptor activity is the variable most commonly studied in models examining energy expenditure and hepatic lipid behaviour, which has positioned retatrutide as the focal compound in current metabolic peptide literature