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Beyond the toxic gain-of-function effects of mHTT, HD pathogenesis involves a range of interconnected mechanisms, including mitochondrial dysfunction, transcriptional dysregulation, impaired autophagy, proteostasis failure, excitotoxicity, oxidative stress, and chronic neuroinflammation [3843]
These are complementary rather than conflicting effects
I do a lot of active things and I just have never been the greatest eater," Whalen explained
Some patients may ask about switching from semaglutide to tirzepatide if weight loss slows, side effects become difficult, blood sugar goals change, or they are not seeing the desired response
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