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What the animal studies cannot tell us includes optimal human dosing, population-specific responses (elderly, children, pregnancy), long-term safety in humans, rare side effects that require large sample sizes to detect, and interactions with medications or medical conditions

Clinical experience from thousands of patients in optimization medicine practices supports its use, but the formal evidence lags behind the clinical adoption

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However, that energy effect is only true to the extent that they were B12 deficient in the first place