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Mechanism of Action When SLU-PP-332 binds to ERR, it activates transcriptional programs normally triggered by endurance exercise, including: Upregulation of PGC-1, the master regulator of mitochondrial gene expression Increased mitochondrial density and oxidative enzyme activity in skeletal and cardiac muscle Enhanced fatty acid oxidation and energy expenditure Improved substrate utilization, as indicated by reduced respiratory exchange ratio (RER) in animal studies
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Thyroid hormone-induced alterations in phospholamban protein expression
