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If any apply, the medication should not be prescribed: Personal or family history of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Known serious hypersensitivity to the active medication or to a related incretin-receptor agonist Clinical precautions that prompt careful screening These are not absolute contraindications on the FDA label, but they meaningfully change the risk-benefit conversation

Khadimallah I, Jenni R, Cabungcal J-H, Cleusix M, Fournier M, Beard E, et al

Lee, P., Greenfield, J

Several providers, including Empower Pharmacy and IVIM Health , offer compounded tirzepatide at lower price points