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Several factors can trigger anemia in malaria patients, including reduced erythrocyte generation in bone marrow, extravascular destruction or hemolysis of erythrocytes, or suicidal death of erythrocytes familiar as eryptosis [210, 403, 404]
Inhibition studies The enzyme activity of GSTP1 was measured using a spectrophotometric assay based on the conjugation of glutathione (GSH) to 1-chloro-2,4-dinitrobenzene (CDNB)
In the liver, it neutralises free radicals produced by Phase 1 liver detoxification of chemical toxins
Testosterones conversion to dihydrotestosterone further enhances this inhibitory effect, reducing CRH and AVP mRNA expression in the PVN, decreasing POMC mRNA in the pituitary, and enhancing GR-mediated feedback 83
