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When macrophages are recruited by adipose tissue due to the overexpression of monocyte chemoattractant protein 1 (MCP1, a chemokine ligand also known as CCL2), hepatic insulin resistance is observed with increased TNF expression in adipose tissue, but without any change in body weight or adiposity [148]
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In vitro , overexpression of PACS-2 in HK-2 cells restores reticulophagy via TFEB/family with sequence similarity 134 member B pathway ( Autophagy disruption is caused by multiple-level abnormalities in upstream signaling pathways (117, 152)
J Med Plants Stud 1:715 Dharmarathna SLCA, Wickramasinghe S, Waduge RN, Rajapakse RPVJ, Kularatne SAM (2013) Does Carica papaya leaf-extract increase the platelet count
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