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Hypersensitivity reactions refer to an immune response resulting in inflammation, tissue damage, and even chronic disease states (such as multiple sclerosis, colitis, arthritis, ADHD, anaphylaxis, and autoimmunity)
It is a synthetic chemical derived from a naturally present substance in the gut
Nat Rev Mol Cell Biol (2007) 8(7):51929.10.1038/nrm2199 114 SchroderMKaufmanRJ
(More on prevention below.) Trial summaries consistently list constipation among common adverse effects
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