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In particular, preclinical studies have demonstrated that GLP-1 and its more stable and long-lasting analogues GLP-1RAs possess neuroprotective and antiapoptotic properties, modulate long-term potentiation and synaptic plasticity, as well as promote the differentiation of neuron precursors, and can reduce depressive behavior [75]

Some patients regain weight after stopping treatment, especially without a maintenance plan

Exclusion criteria included unreliably extracted data, non-English language studies, books, conference papers, case reports, and articles without full text, and non-original articles like reviews and meta-analyses

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