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Lipids potently increase CCK release 180,181 , and administration of CCK-1R antagonists blocks the satiating effects of intestinal lipid infusion in both rodents and humans 169,182
Research context Across published scientific work, DSIP has been examined in several research settings, including circadian signaling, cellular stress responses, nociception models, mood-linked neurochemistry models, reward-pathway models, and also cell proliferation and oncology-related models
Among the observations from microdosing patients, some have reported non-scale changes they attribute to reduced inflammation
Others are early in research but backed by data that demands attention
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