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Porridge manages appetite biology directly, not just caloric intake

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Metformin induces TPC-1 cell apoptosis through endoplasmic reticulum stress-associated pathways in vitro and in vivo

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Clinicians should screen for history of pancreatitis, severe gastrointestinal disease (particularly severe gastroparesis), diabetic retinopathy (particularly if intensifying glycemic control rapidly), and gallbladder disease, as these conditions may influence treatment decisions or require closer monitoring

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