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*Correspondence: Bin Chen [email protected] This article was submitted to Food Chemistry, a section of the journal Frontiers in Nutrition Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Injection Timing & Technique Administer in the evening to mitigate nausea Always use sterile syringes and bacteriostatic water Inject into abdominal or thigh subcutaneous tissue Clean injection site thoroughly before administration Storage Guidelines Store lyophilized powder in a cool, dry, and dark place before mixing Once reconstituted, refrigerate and use within 3060 days Keep vials sealed and avoid contamination Proper storage and handling preserve the potency and stability of Melanotan II and reduce the risk of infection or degradation

CONCLUSION Both TA and glutathione intradermal microinjections were effective in the treatment of facial melasma

Dose can be further increased by 2.5 mg every four weeks to a maximum dose of 15 mg once weekly as required