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Uncommon and rare adverse effects include cystitis, folliculitis, gastrointestinal infections, hypersensitivity reactions, changes in appetite, depression, insomnia, balance disorders, lethargy, restless leg syndrome, syncope, photophobia, presbyopia, tinnitus, confusion, palpitations, hypertension, hypercholesterolaemia, and weight gain

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In addition to healthy diet and lifestyle habits, preliminary studies have shown beneficial effects of supplemental glutathione in the treatment of NAFLD, demonstrating a reduction of ALTa liver enzyme elevated in liver dysfunction and one of the principal NAFLD biomarkersafter four months of treatment

Low SAM or elevated SAH may reduce SAM-dependent methyltransferase activity involved in catecholamine metabolism, potentially prolonging inner tension and nighttime arousal