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Abstract Fibrosis is a public health issue of great concern characterized by the excessive deposition of extracellular matrix, leading to the destruction of parenchymal tissue and organ dysfunction that places a heavy burden on the global healthcare system due to its high incidence, disability, and mortality
Subtypes of Group I include mGluR1 and mGluR5 receptors conjugated with Gq/G11 (Nicoletti et al., 2011)
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Interferon-alpha triggers autoimmune thyroid diseases via lysosomal-dependent degradation of thyroglobulin
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