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[24] Deficiency [edit] Vitamin B 12 deficiency can potentially cause severe and irreversible damage, especially to the brain and nervous system
Kidney disease or renal insufficiency, where amino acid overload may pose a risk
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FDA's evaluation concluded that the criteria weighed against placement on the list, citing inadequate physicochemical characterization, immunogenicity concerns from impurities and aggregates, lack of clinical effectiveness data for any approved use, and absence of published human exposure data for the proposed subcutaneous and topical routes
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