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As estrogen declines during perimenopause and menopause, the hypothalamus is already under significant strain
Drugs.com Gillessen, A., & Schmidt, H
In pancreatic beta cells, GLP-1RA promotes the conversion of proinsulin to mature insulin by upregulating the expression of hormone converting enzymes PC1/3 and PC2, while reducing the proinsulin/insulin ratio and enhancing insulin biological activity
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