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5 Immune system irregularities (eg, autoimmunity, chronic inflammation), undetected chronic infection, inflammation and/or hyperexcitability of the bladder nerves, and altered signaling between the bladder and other pelvic tissues may also contribute

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[oai_citation:4PubMed]( [oai_citation:5PMC]( 4) Growth-hormone receptor (GHR) expression in tendon fibroblasts Gene-expression and protein studies found dose- and time-dependent up-regulation of GHR