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GLP-1/GIP twincretins therefore show some promise at this stage

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As noted by others ( Of note, the finding of a markedly greater benefit on HF of efpeglenatide amongst trial participants using SGLT2 inhibitors at enrolment in the AMPLITUDE-O CVOT highlights another important point (Lam et al., 2021)

GLP-1 receptors are expressed in bone tissue, and preclinical studies have explored their role in bone metabolism