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Patients may experience musculoskeletal discomfort from increased physical activity (often motivated by improved energy), reduced anti-inflammatory medication use, or pre-existing arthritis exacerbated by weight changes
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However, Retatrutide also mimics glucagon in addition to glucagon-like peptide 1 , allowing it to work as a triple agonist
The synergistic effect of medication and exercise typically results in greater total weight loss, improved body composition, and enhanced metabolic health compared to medication alone
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